My primary activities are both running an NIH-funded diabetes research laboratory and the Energy Balance Core facility at the BIDMC. I am best known for research into the molecular and genetic mechanisms driving differences in metabolic physiology. By generating genetically modified mice with specific mutations, my work has helped to understand pathways critical to obesity, aging, and diabetes. We revealed the effects of the adipose tissue to control whole-body glucose homeostasis through post-translational modifications of PPAR-gamma. We have also contributed an analysis tool to de-convolute obesity and energy balance data which has quickly become the worldwide standard.