I am the Chief Research Informatics Officer and Marsico Chair in Data Science at the University of Colorado Anschutz Medical Campus, and the Director of the Center for Data to Health (CD2H). My background is in molecular genetics and developmental biology as well as translational informatics, with a focus over the past decade on open science and semantic engineering. My vision is to weave together healthcare systems, basic science research, and patient-generated data through the development of data-integration technologies and innovative data capture strategies. Through my leadership of the Monarch Initiative, we have led the field in the integration of genotype-phenotype data across species to improve rare-disease diagnosis and mechanism discovery. Working together across disciplines to harmonize data and knowledge in a process I refer to as "socio-technical engineering" - where the data AND the people are harmonized to achieve shared but sometimes hidden goals. Through the use of such socio-technical engineering strategies, I have also led the creation of the National Covid Cohort Collaborative (N3C), the largest national, publicly available harmonized HIPAA-limited dataset in US history. I also lead and participate in a variety of international standards organizations to support improved data sharing and utility worldwide. Finally, I am a dedicated mentor and focus on the creation and health of diverse teams to advance societal challenges.